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HCG Halflife?

HCG Halflife?
I think im reading this wrong but does it say HCGs half life is 3 days? I never read anywhere about a half life of HCG.
http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus
The decline of serum levels of AFP or HCG in 26 patients with disseminated non-seminomatous germ cell tumors during chemotherapy showed two different patterns: a linear decline or an increasing apparent half life (AHL). The initial AFP half life in 13 patients with a linear decline was 7.2 +/- 1.8 days, and did not differ from the initial half life in 5 patients with a curvi-linear pattern. HCG half life was 3.0 +/- 0.5 days in 10 patients with a linear AHL, and was not different from the initial half life in 6 patients with delayed marker disappearance. Based on the half life pattern of AFP or HCG the result of chemotherapy was predicted. When AFP or HCG showed a linear decline, all viable tumor appeared to be eliminated in 38 and 40% respectively of the patients. An increasing AHL indicated the presence of active tumor, mostly mature teratoma, in 60% of the patients with AFP and in 83% of the patients with HCG. Thus, the pattern of AFP or HCG half life does not predict the eventual outcome of chemotherapy with certainty.

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Hey man. I've been reading the half life is 36h. That's why some guys are suggesting 100iu/ed on cycle.

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Hey man. I've been reading the half life is 36h. That's why some guys are suggesting 100iu/ed on cycle. Really, where did you hear that man?

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Hey monster, have you read Anabolics 2007? It has a section for hCG. It's kind of long, but I will type it all out if you need. Also, if someone from Molecular Nutrition has a problem with it, I may have to delete it soon after.

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Hey monster, have you read Anabolics 2007? It has a section for hCG. It's kind of long, but I will type it all out if you need. Also, if someone from Molecular Nutrition has a problem with it, I may have to delete it soon after. Nope never read it. Im going to buy it one of these days though. Ive read some of the authors articles though.

Answer:

Nope never read it. Im going to buy it one of these days though. Ive read some of the authors articles though. It's a good informative book to have. The cycle section could use some work, but the actual info is great. The only thing it says about hCG's half-life is:
Human Chorionic Gonadotropin is generally given by intramuscular ( IM ) injection. The subcutaneous route is also used, and has been deemed to be roughly equivalent therapeutically to IM injections. Peak conecentrations of chorionic gonadotropin occur approximately 6 hours after intramuscular injection, and 16 to 20 hours after subcutaneous injection.
And for usage on-cycle:
Bodybuilders and athletes may also administer Human Chorionic Gonadotropin throughout a steroid cycle, in an effort to avoid testicular atrophy and the resulting reduced ability to respond to LH stimulus. In effect, this practice is used to avoid the problem of testicular atrophy, instead of trying to correct it later on when the cycle is over. It is important to remember that the dosage needs to be carefully monitored with this type of use, as high levels of hCG may cause increased testicular aromatase expression ( raising estrogen levels ), and also desensitize the testes to LH. As such, the drug may actually induce primary hypogonadism when misused, greatly prolonging, not improving, the recovery window. Current protocols for the use of hCG in this manner involve administering 250IU subcutaneously twice per week ( every 3rd or 4th day ) throughout the length of the steroid cycle. Higher doeses may be necessary for some individuals, but at no point should exceed 500IU per injection.
There is a lot more info if you need it. Hope this helps.

Answer:

It's a good informative book to have. The cycle section could use some work, but the actual info is great. The only thing it says about hCG's half-life is:
Human Chorionic Gonadotropin is generally given by intramuscular ( IM ) injection. The subcutaneous route is also used, and has been deemed to be roughly equivalent therapeutically to IM injections. Peak conecentrations of chorionic gonadotropin occur approximately 6 hours after intramuscular injection, and 16 to 20 hours after subcutaneous injection.
And for usage on-cycle:
Bodybuilders and athletes may also administer Human Chorionic Gonadotropin throughout a steroid cycle, in an effort to avoid testicular atrophy and the resulting reduced ability to respond to LH stimulus. In effect, this practice is used to avoid the problem of testicular atrophy, instead of trying to correct it later on when the cycle is over. It is important to remember that the dosage needs to be carefully monitored with this type of use, as high levels of hCG may cause increased testicular aromatase expression ( raising estrogen levels ), and also desensitize the testes to LH. As such, the drug may actually induce primary hypogonadism when misused, greatly prolonging, not improving, the recovery window. Current protocols for the use of hCG in this manner involve administering 250IU subcutaneously twice per week ( every 3rd or 4th day ) throughout the length of the steroid cycle. Higher doeses may be necessary for some individuals, but at no point should exceed 500IU per injection.
There is a lot more info if you need it. Hope this helps. Thanks for that man, found what I was looking for.

Answer:

Just FYI: Pregnyl hCG
Pharmacokinetics
Maximal plasma hCG levels will be reached in males approximately 6 and 16 hours after a single intramuscular or subcutaneous injection of hCG, respectively and in females after approximately 20 hours. HCG is approximately 80 per cent metabolized, predominantly in the kidneys. Intramuscular and subcutaneous administration of hCG were found to be bioequivalent regarding the extent of absorption and the apparent elimination half-lives of approximately 33 hours. On basis of the recommended dose regimens and elimination half-life, cumulation is not expected to occur.
http://home.intekom.com/pharm/donmed/pregnyl.html

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So I guess it is best to shoot 100IU's ED then?

Answer:

Hey SM,
I do 100IU ed but not everyone wants to hassle with that. If you are inj twice a week you could run 250IU with each.
In my opinion even 1500IU ew is not enough to keep everything operating.
Approximation for Illustration: 1.5 days is 36 hours
High IU ew inj.
Day-0 1500IU inj.
Day-1.5 750IU
Day-3 375IU
Day-4.5 188IU
Day 6 94IU
Day 7.5 47IU
Low IU 100IU ed inj. with a 33 hour half-life we build up not waste stimulation.
Example with only a 24 hour half-life.
Day-0 100IU
Day-1 150IU
Day-2 175IU
Day-3 186IU
Day-4 193IU
etc...
Should max at around 200IU consistently for the cycle period.
Low IU gives a constant stimulation without essentially wasting your hCG also.

Answer:

Dude if I could rep you I would. Thank You.
Hey SM,
I do 100IU ed but not everyone wants to hassle with that. If you are inj twice a week you could run 250IU with each.
In my opinion even 1500IU ew is not enough to keep everything operating.
Approximation for Illustration: 1.5 days is 36 hours
High IU ew inj.
Day-0 1500IU inj.
Day-1.5 750IU
Day-3 375IU
Day-4.5 188IU
Day 6 94IU
Day 7.5 47IU
Low IU 100IU ed inj. with a 33 hour half-life we build up not waste stimulation.
Example with only a 24 hour half-life.
Day-0 100IU
Day-1 150IU
Day-2 175IU
Day-3 186IU
Day-4 193IU
etc...
Should max at around 200IU consistently for the cycle period.
Low IU gives a constant stimulation without essentially wasting your hCG also.

Answer:

Really, where did you hear that man? "Recap ? For optimal preservation of testicular function during cycle, use 100iu hCG ED starting 3 days after your first AAS dose. Drop the hCG a week before the AAS clear the system. For example, you would drop hCG a week after your last Testosterone Enanthate shot. Or, if you are ending the cycle with orals, you would drop the hCG a week before your last oral dose. This will allow for a sudden and even drop in hormone levels, while initiating LH and FSH production from the pituitary, making for a seamless recovery."
"Based on studies with normal men using steroids, ~100iu HCG administered everyday was enough to preserve full testicular function and ITT levels, without causing desensitization typically associated with higher doses of hCG. It is important that low-dose hCG is started before testicular degeneration occurs, which appears to rapidly manifest within the first 2-3 weeks of steroid use."
I can't post a link from SSB, but search for "Everything That's Wrong With Your PCT"

Answer:

"Recap ? For optimal preservation of testicular function during cycle, use 100iu hCG ED starting 3 days after your first AAS dose. Drop the hCG a week before the AAS clear the system. For example, you would drop hCG a week after your last Testosterone Enanthate shot. Or, if you are ending the cycle with orals, you would drop the hCG a week before your last oral dose. This will allow for a sudden and even drop in hormone levels, while initiating LH and FSH production from the pituitary, making for a seamless recovery."
"Based on studies with normal men using steroids, ~100iu HCG administered everyday was enough to preserve full testicular function and ITT levels, without causing desensitization typically associated with higher doses of hCG. It is important that low-dose hCG is started before testicular degeneration occurs, which appears to rapidly manifest within the first 2-3 weeks of steroid use."
I can't post a link from SSB, but search for "Everything That's Wrong With Your PCT" Ohhhhhhhhhh that article, read it alllllong time ago, completely forgot about it untill now. Thank you too dude, im def saving this thread for next cycle when I will be running it throughout.

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Ohhhhhhhhhh that article, read it alllllong time ago, completely forgot about it untill now. Thank you too dude, im def saving this thread for next cycle when I will be running it throughout. Oh man, it's so confusing how to use HCG... I will use it pretty soon in my second cycle. I will use 2X250iu/weekly with adex on cycle. Pct will be aromasin+nolva. I won't use hcg during pct. Anthony Robert recommended it, but most studies don't.

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Oh man, it's so confusing how to use HCG... I will use it pretty soon in my second cycle. I will use 2X250iu/weekly with adex on cycle. Pct will be aromasin+nolva. I won't use hcg during pct. Anthony Robert recommended it, but most studies don't. I dont like all of AR's articles nor HCG durring PCT either(Supresses you). Ok since the HL is around a day wouldn;t the levels be all over the place doing it that way? I want to do 500IUs every week also but im just a little concerned about the levels, I know HCG also causes more acne(which I think im experiencing, or well longer lasting). Still have a lot more research to do though.





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